Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain
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چکیده
منابع مشابه
Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain
Toxoplasma gondii is an obligatory intracellular apicomplexan protozoan which can infect any warm-blooded animal and causes severe diseases in immunocompromised individuals or infants infected in utero. The survival and success of this parasite require that it colonizes the host cell, avoids host immune defenses, replicates within an appropriate niche, and exits the infected host cell to spread...
متن کاملThe Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection
UNLABELLED Ingestion of the obligate intracellular protozoan parasite Toxoplasma gondii causes an acute infection that leads to chronic infection of the host. To facilitate the acute phase of the infection, T. gondii manipulates the host response by secreting rhoptry organelle proteins (ROPs) into host cells during its invasion. A few key ROP proteins with signatures of kinases or pseudokinases...
متن کاملFunctional Analysis of the Rhoptry Kinome during Chronic Toxoplasma gondii Infection
Toxoplasma gondii is one of the most common parasitic infections of humans worldwide. Once exposed, humans remain infected with T. gondii for life, and there are no therapeutics capable of eliminating a chronic infection. In the search for novel drug targets, T. gondii is known to contain several unique secretory organelles, one of which is called the rhoptries. Rhoptry organelles contain and s...
متن کاملCloning rhoptry protein 1 (ROP1) gene of Toxoplasma gondii (RH) in expression vector
Toxoplasma gondii contain various immunogenic antigens. The most important Toxoplasma antigens are somatic and excreted/secreted antigens. Rhoptry proteins are known as excreted/secreted antigens. These antigens have been proposed as a vaccine candidate against toxoplasmosis. The main objective of the present work was cloning rhoptry protein1 (ROP1) Gene of Toxoplasma gondii (RH) in a cloning...
متن کاملcyst formation from virulent rh strain of toxoplasma gondii tachyzoite: in vitro cultivation
background: this study was performed to induce conversion of rh strain tachyzoites of toxoplasma gondii to bradyzoites by ph changing of the culture medium. methods: hela cell monolayers were infected at a 1:1 tachyzoite to cell ratio. four hours after infection, the culture medium was removed and replaced with culture medium and 5% fcs, adjusted to ph 8 with naoh. the culture was maintained ...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2017
ISSN: 1664-302X
DOI: 10.3389/fmicb.2017.00084